| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223281 | Tetrahedron | 2010 | 13 Pages |
Abstract
Complete details of thiazole syntheses by scandium-catalyzed cycloaddition reactions of 1-aryl- and 1,1-bisaryl-3-phenylsulfanylpropargyl alcohols with thioamides are described. Reactions of 1,1-bisarylpropargyl alcohols with thioamides and selenamide in MeNO2/H2O resulted in 4-bisarylmethyl-1,3-thiazoles 4aa-ic and 4H-4,4-bisaryl-1,3-thiazines 5ea-ga in high yields. Reactions in MeNO2/D2O resulted in 4-bisaryldeuteriomethyl-1,3-thiazoles 10ca-ia with high deuterium purity. Reactions of dialkyl and alkyl aryl propargyl alcohols are also described.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Mitsuhiro Yoshimatsu, Miki Matsui, Teruhisa Yamamoto, Arisa Sawa,