| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223327 | Tetrahedron | 2009 | 5 Pages |
Abstract
A regio- and stereoselective synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated coupling reactions was developed. The comparison and optimization of stereoselectivity of the Heck, Stille, and Suzuki reactions of 7-bromo or 7-triflate-3-quinolinecarbonitrile are described. Compound 7 and 10 were potent inhibitors of Src kinase and Raf/Mek activity, respectively.
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Chemistry
Organic Chemistry
Authors
Yanong D. Wang, Minu Dutia, M. Brawner Floyd, Amar S. Prashad, Dan Berger, Melissa Lin,