Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223337 | Tetrahedron | 2009 | 9 Pages |
Abstract
The reaction of 5-polyfluoroaryl-1,2,4-oxadiazoles with methylhydrazine has been studied and the synthesis of fluorinated N-methylindazoles has been realized. Rearrangement reactions showed predominantly formation of N(1)-methylindazole regioisomers. Starting compounds were preliminarily functionalized at the polyfluoroaryl moiety through fluorine displacement with nucleophiles (methanol, methylamine, dimethylamine), allowing the obtainment of target indazoles substituted at the C(6) position.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Antonio Palumbo Piccionello, Andrea Pace, Paola Pierro, Ivana Pibiri, Silvestre Buscemi, Nicolò Vivona,