| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223402 | Tetrahedron | 2010 | 6 Pages |
Abstract
A new family of compounds made of a 5-aryl-1H-imidazole motif included in a macrocycle has been designed and synthesized. The synthesis of the imidazole core makes use of our previously developed method for the regioselective preparation of 1,2,5-trisubstituted imidazoles while the construction of the macrocycle is based on a three steps sequence: SNAr, Suzuki coupling, and RCM reaction. Biological evaluation of synthesized imidazole-containing macrocycles revealed that they display actual binding activity toward A3 adenosine (h) receptor, dopamine D1 (h) receptor, chloride channel (GABA-gated), and choline transporter (h) CHT1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Prosper Nshimyumukiza, Emilie Van Den Berge, Bruno Delest, Tatjana Mijatovic, Robert Kiss, Jacqueline Marchand-Brynaert, Raphaël Robiette,