Article ID Journal Published Year Pages File Type
5223432 Tetrahedron 2009 7 Pages PDF
Abstract

A Mannich-type three-component reaction involving aldehydes, acetamide, and enolizable ketones or β-keto esters for the preparation of β-acetamido carbonyl compounds in the presence of TMSCl is described. This newly developed protocol is operationally convenient, widely applicable, and highly diastereoselective.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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