| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223447 | Tetrahedron | 2010 | 6 Pages |
Abstract
Enantioselective alkynylation of aldehydes and ketones was accomplished using trimethoxysilylalkynes as alkynylating reagents and lithium 3,3′-diphenylbinaphtholate as a catalyst. Optically active propargylic alcohols were obtained in good to high chemical yields and enantioselectivities. Alkynylation of acetylpyridines afforded biologically active pyridyl propargylic alcohols in good enantioselectivities.
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