| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223449 | Tetrahedron | 2010 | 5 Pages |
Abstract
An efficient scaled-up synthesis of 11 utilizing a CoBr2/Zn-catalyzed [2+2+2] cycloaddition reaction has been developed, allowing the preparation of compound 2, a building block for sila-substituted drugs, on a multi-gram scale.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Large-scale synthesis of 1,1,3,3,6-pentamethyl-1,3-disilaindan-5-ol via a CoBr2/Zn-catalyzed [2+2+2] cycloaddition reaction](/preview/png/5223449.png "First Page Preview: Large-scale synthesis of 1,1,3,3,6-pentamethyl-1,3-disilaindan-5-ol via a CoBr2/Zn-catalyzed [2+2+2] cycloaddition reaction")
Authors
Ryo Mizojiri, Richard Conroy, Jürgen Daiss, Etsuo Kotani, Reinhold Tacke, David Miller, Louise Walsh, Tetsuji Kawamoto,