| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223452 | Tetrahedron | 2010 | 7 Pages |
Abstract
A new, efficient, and inexpensive CuCl2/salicylic acid catalytic system has been developed to catalyze Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes under mild reaction conditions to afford the corresponding coupling products in 18-95% yields. The role of salicylic acid might act as a bidentate O,O-donor ligand to activate the catalytic reactivity of copper chloride in coupling reactions was also briefly discussed.
Graphical abstractA new and efficient CuCl2/salicylic acid catalytic system has been developed to catalyze Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Horung-Jyh Chen, Zhe-Yi Lin, Meng-Yuan Li, Ruei-Jheng Lian, Qing-Wen Xue, Jui-Lun Chung, Shu-Chih Chen, Yao-Jung Chen,