Lateral lithiation in terpenes: synthesis of (+)-ferruginol and (+)-sugiol

This paper describes the use of (−)-sclareol in the synthesis of the tricyclic diterpenes of abietane skeleton, such as (+)-ferruginol and (+)-sugiol, using as key step the lateral lithiation of a dinorditerpene derivative.

Graphical abstract(+)-Ferruginol and (+)-sugiol have synthesised from (−)-sclareol, using lateral lithiation as key reaction.Figure optionsDownload full-size imageDownload as PowerPoint slide