| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223523 | Tetrahedron | 2010 | 9 Pages |
Abstract
A series of neovibsanin A and B derivatives and lower homologues were synthesized to study their neurotrophic ability with PC12 cells. 4,5-Bis-epi-neovibsanin A displayed prominent ability to induce neurite outgrowth compared to control cultures. Herein we describe the total synthesis of 4,5-bis-epi-neovibsanin A and B as well as comparing the biological activity of several neovibsane derivatives.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Annette P.-J. Chen, C. Catharina Müller, Helen M. Cooper, Craig M. Williams,