| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223536 | Tetrahedron | 2010 | 4 Pages |
Abstract
An efficient one-pot synthesis of pyrimido[6,1-a]isoquinoline-1-carboxylate derivatives is described. This involves the four-component reaction between primary amines, alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature.
Graphical abstractA facile and direct synthetic entry to pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction of primary amines and alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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