| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223563 | Tetrahedron | 2010 | 5 Pages |
Abstract
We describe a rapid and efficient method for selective deprotection of methoxymethyl (MOM) ethers using ZnBr2 and n-PrSH, which completely removed MOM from diverse MOM ethers of primary, secondary, and tertiary alcohols or phenol derivatives. The deprotection takes less than ten minutes with both high yield and selectivity in the presence of other protecting groups. In addition, the rapid deprotection of MOM ethers of tertiary hydroxyls in high yield with no epimerization allows MOM to be a suitable protecting group for tertiary alcohols.
Graphical abstractMOM ethers of primary, secondary, tertiary and phenolic hydroxyls.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jae Hyun Han, Young Eun Kwon, Jeong-Hun Sohn, Do Hyun Ryu,