Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223665 | Tetrahedron | 2010 | 9 Pages |
Abstract
Although direct, asymmetric, halonium-induced cyclizations have proven difficult to achieve in the absence of enzymes, this report provides a two-step alternative based on reacting polyenes with chiral mercury(II) complexes to afford a number of polycyclic organomercurials that can be subsequently converted, with retention, into their corresponding chlorine, bromine, and iodine derivatives in good yield and enantioselectivity. A five-step asymmetric total synthesis of the natural product 4-isocymobarbatol is also described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott A. Snyder, Daniel S. Treitler, Andreas Schall,