| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223676 | Tetrahedron | 2010 | 6 Pages |
Abstract
A rapid synthetic approach to the tylophora alkaloids antofine and 13aα-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction as the key step. This reaction, along with a one-pot, three-step telescoped process offers a three or four-pot sequence to access the title compounds in high overall yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lisa M. Ambrosini, Tim A. Cernak, Tristan H. Lambert,