| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223719 | Tetrahedron | 2008 | 9 Pages |
Abstract
The direct Mukaiyama–Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et3N mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly manipulable γ-substituted pyrrolinone products were practically synthesized in acceptable to excellent yields, and with diastereoselectivities heavily relying upon the substituent at the nitrogen atom of the pyrrolinone donor.
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