Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223720 | Tetrahedron | 2008 | 7 Pages |
Abstract
The Ugi reaction with CF3-carbonyl compounds is described in detail. The method is efficient for the multicomponent preparation of α-trifluoromethyl (Tfm) amino acids, α-Tfm containing dipeptides, and iminodicarboxylic acids. In addition, the first protected CF3-opine derivative was prepared. The scope, limitations, and stereochemistry of the approach are discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anton V. Gulevich, Nikolay E. Shevchenko, Elisabeth S. Balenkova, Gerd-Volker Röschenthaler, Valentine G. Nenajdenko,