Article ID Journal Published Year Pages File Type
5223721 Tetrahedron 2008 5 Pages PDF
Abstract

A convenient one-step synthesis of chiral γ-lactones has been performed. The method is based on enantioselective hydrogenation of γ-ketoesters using the RuCl3-BINAP-HCl catalytic system. Chiral γ-lactones (91-99% ee) have been isolated in 57-88% yield.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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