Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223784 | Tetrahedron | 2010 | 6 Pages |
Abstract
The new type of solvent-free cascade reaction was found: the direct heating of the mixture of salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes at 60 °C in the presence of catalytic amounts of KF or NaOAc results in the formation of 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carbonitriles or methyl 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carboxylates in 80-90% yields. Thus, the new simple and efficient solvent-free 'one-pot' way to substituted medicinally privileged 2-amino-4H-chromene scaffold was found directly from such simple and reasonable starting compounds as salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michail N. Elinson, Alexey I. Ilovaisky, Valentina M. Merkulova, Pavel A. Belyakov, Alexander O. Chizhov, Gennady I. Nikishin,