| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5223849 | Tetrahedron | 2010 | 9 Pages |
Abstract
Construction of the C(1)-C(25) southern fragments of both spirastrellolide A and B are described. Highlights of the syntheses include effective use of the three component anion relay chemistry (ARC) tactic recently introduced by our laboratory, a stereoselective spirocyclization via concomitant Ferrier reaction to elaborate the BC spiroketal and use of two dithiane unions to install the A ring as well as C(22)-C(25) fragment. The synthesis proceeded with longest linear sequences of 33 and 32 steps, respectively for spirastrellolide A and spirastrellolide B.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amos B. III, Helmars Smits, Dae-Shik Kim,