Article ID Journal Published Year Pages File Type
5223870 Tetrahedron 2010 6 Pages PDF
Abstract

A self-catalytic protocol was developed using an aza-Friedel-Crafts method to generate 1-naphthoyl tetrahydroisoquinoline products under solvent-free conditions or in/on water. Yields were increased with the use of water. The reaction proceeded with 100% atom economy in the absence of any additional catalyst.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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