Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5223916 | Tetrahedron | 2008 | 8 Pages |
Abstract
A mild, highly efficient and metal-free synthetic method for aromatization of 1,4-dihydropyridines employing urea-hydrogen peroxide adduct as oxidant catalyzed by 20 mol % of molecular iodine was developed. The reaction was carried out in ethyl acetate at room temperature and the products were isolated in high to excellent yields. A plausible free-radical mechanism is proposed based on results obtained with derivatives having alkyl and aryl substituents in the 1,4-dihydropyridine ring.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mirela Filipan-LitviÄ, Mladen LitviÄ, Vladimir VinkoviÄ,