| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224037 | Tetrahedron | 2010 | 6 Pages |
Abstract
Efficient synthetic routes to both syn and anti diastereomers of a conformationally restricted 1,3-aminoalcohol were devised. Resolution of the aminoalcohols was accomplished through diastereomeric salt with R-(−)-O-acetyl mandelic acid. These aminoalcohols were examined as ligands for two standard reactions, namely, enantioselective addition of Et2Zn to aldehydes and reduction of prochiral ketones with BH3.
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