| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224046 | Tetrahedron | 2010 | 5 Pages |
Abstract
An efficient and novel synthesis of 6,9-disubstituted purin-8-ones has been developed. Starting from dichloropyrimidin-5-ylcarbamate, CuCl/amino acid catalyzed coupling/cyclization reaction with amines was achieved to afford 9-substituted 6-chloropurin-8-ones. Then a microwave-assisted amination procedure was carried out for the synthesis of 6,9-disubstituted purin-8-ones in moderate to good yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qi-Fei Zhong, Li-Ping Sun,