| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224125 | Tetrahedron | 2010 | 5 Pages |
Abstract
The efficiency of a cyclodehydration reaction leading to benzodiazepinones is markedly improved by N-methylation of the amide link connecting the nucleophile and the electrophile, which is attributed to its favouring both the more reactive E-rotamer and the exit of the leaving group.
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Related Topics
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![Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions](/preview/png/5224125.png "First Page Preview: Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions")