Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224153 | Tetrahedron | 2009 | 8 Pages |
Abstract
Reduction of cyclopropylmethylamines proceeded under mild reaction conditions in the presence of platinum (IV) oxide catalyst and hydrobromic acid at rt, providing isobutylamines and no linear butylamines. The ring cleavage reaction was widely applicable to cyclopropane rings in various compounds such as N-cyclopropylalkyl, O-cyclopropylalkyl, and C-cyclopropylalkyl derivatives. Although unactivated cyclopropane rings were also cleaved, the cyclobutane ring was tolerated under the same reaction conditions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hideaki Fujii, Kayoko Okada, Marina Ishihara, Shinichi Hanamura, Yumiko Osa, Toru Nemoto, Hiroshi Nagase,