Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224189 | Tetrahedron | 2008 | 9 Pages |
Abstract
4-Aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidine derivatives were prepared using a multicomponent reaction by reacting a mixture of arene or heteroarenecarbaldehyde, 1,3-dicarbonyl compounds, and cyanamide under acidic conditions. The novelty of this approach derives from its use of cyanamide as a building block in a four-component Biginelli-type reaction. Varying the reaction conditions led to the formation of either N-(2-imino-6-phenyl-1,3,5-oxadiazinan-4-ylidene) cyanamide or 3,4-dihydropyrimidin-2(1H)-one. The type of heterocycle skeleton synthesized depends on the nature of the acid catalyst as well as the reaction conditions employed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
R. Hulme, O.D.P. Zamora, E.J. Mota, M.A. Pastén, R. Contreras-Rojas, R. Miranda, I. Valencia-Hernández, J. Correa-Basurto, J. Trujillo-Ferrara, F. Delgado,