Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224202 | Tetrahedron | 2010 | 13 Pages |
Abstract
A number of highly substituted 1,3-dienes and 1,3,5-trienes have been stereoselectively prepared in moderate to good yields by the coupling of vinylic iodides, internal alkynes, and organoboranes in the presence of a palladium catalyst. Optimal reaction conditions for different organoboron substrates have been developed. The analogous three-component coupling of aryl halides, 1,3-cyclohexadiene, and boronic acids provides a synthetically useful route to 3,6-disubstituted cyclohexenes. These methods are very efficient and provide an expeditious way to synthesize the indicated alkenes, dienes, and trienes, whose preparation would normally require multi-step synthesis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoxia Zhang, Richard C. Larock,