| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224226 | Tetrahedron | 2008 | 7 Pages |
Abstract
Sequential exposure of a zinc-organometallic intermediate, generated through a zinc carbenoid-mediated chain extension reaction of a β-keto carbonyl, to trimethylsilylchloride and iodine provided regioselective formation of an α-iodomethyl-γ-keto carbonyl. The iodomethyl functionality can be further manipulated to provide side chains that are potential mimics of α-amino acid side chains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qinglin Pu, Emerald Wilson, Charles K. Zercher,