| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224235 | Tetrahedron | 2008 | 15 Pages |
Abstract
The structural diversification of four 4(20),11(12)-taxadienes (sinenxan A and its two derivatives, and yunanxane) by microbial/plant whole-cell enzymatic transformation has been achieved; 53 derivatives have been obtained, and 41 of them are new compounds. The occurred reactions exhibited diversity, including hydroxylation, epoxidation, oxidation, hydrolysis, acylation, O-alkylation, O-glycosylation, rearrangement, etc. In addition, one chemical derivative, 9α-cinnamoyl sinenxan A from one enzymatic product 9α-hydroxyl sinenxan A, displayed significant reversal activity toward three MDR tumor cell lines (A549/taxol, KB/VCR, and HCT-8).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jungui Dai, Runjiang Qu, Jian-hua Zou, Xiaoguang Chen,