| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224236 | Tetrahedron | 2008 | 11 Pages |
Abstract
Nafuredin (1) is converted to nafuredin-γ (2) under mild basic conditions and both compounds exhibit the same inhibitory activity and selectivity against NADH-fumarate reductase (complex I). The total synthesis of 2 was achieved by a convergent approach using Stille coupling. The structural elements required for inhibitory activity against NADH-fumarate reductase (complex I) were then investigated by evaluation of nafuredin-γ (2) and its structural analogues.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tohru Nagamitsu, Daisuke Takano, Miyuki Seki, Shiho Arima, Masaki Ohtawa, Kazuro Shiomi, Yoshihiro Harigaya, Satoshi Åmura,