Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224241 | Tetrahedron | 2008 | 4 Pages |
Abstract
A practical synthesis of optically pure PPARα agonist, (R)-K-13675, is described. This process is based on the use of (S)-2-hydroxybutyrolactone, which can be transformed into the requisite n-butyl (S)-2-hydroxybutanoate in an efficient manner. A key reaction is the etherification between the phenol and n-butyl (S)-2-trifluoromethanesulfonyloxybutanoate to give the phenyl ether in excellent yield without loss of optical purity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya,