| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224266 | Tetrahedron | 2009 | 9 Pages |
Abstract
We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tadashi Ema, Norichika Ura, Masataka Yoshii, Toshinobu Korenaga, Takashi Sakai,