| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224292 | Tetrahedron | 2008 | 9 Pages |
Six 12-hydroxybriaranes, including four new diterpenoids, briaexcavatins I–L (1–4), and two known metabolites, excavatolides C (5) and E (6), have been isolated from the cultured scleraxonia Briareum excavatum. In addition, the gorgonian coral Junceella fragilis yielded a new chlorinated briarane, fragilide C (10). The structures of above compounds were determined by spectroscopic methods and the structures of 5 and 6 were further confirmed by X-ray data analysis for the first time. The absolute configuration of 6 was elucidated by chemical conversion. Some of these briaranes have displayed inhibitory effects on superoxide anion generation by human neutrophils.
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