| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224318 | Tetrahedron | 2010 | 5 Pages |
Abstract
Hexafluoroisopropanol (HFIP) was found to be a powerful electrophilic activator of covalent reagents. Due to this effect the title reaction was shown to proceed under mild conditions in the absence of any Lewis acid catalysts to give the respective products of C-alkylation in good to excellent yields.
Graphical abstractElectrophilic activation is achieved using hexafluoroisopropanol (HFIP) as a medium and an electrophilic driver.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maxim O. Ratnikov, Vasily V. Tumanov, William A. Smit,