Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224409 | Tetrahedron | 2009 | 5 Pages |
Abstract
A new preparative method for pyrido[2,3-b][1,4]oxazines from 6-substituted 3-nitro-2-pyridones is demonstrated. This method consists of two steps: O-alkylation and reductive cyclization. In the former step, the bulkiness of both starting nitropyridones and C2 reagents is found to be essential for avoiding N-alkylation, which undergoes O-alkylation efficiently. The subsequent reductive cyclization affords pyridoxazines with carbon substituents at both the 2- and the 6-positions that have not been available.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nagatoshi Nishiwaki, Masataka Hisaki, Masaki Ono, Masahiro Ariga,