| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224426 | Tetrahedron | 2009 | 7 Pages |
Abstract
Regiodivergent 1,2-rearrangement of α-siloxy aldehydes bearing α-aryl and α-alkyl substituents into α-siloxy ketones has been realized by using different Al Lewis acid catalyst/solvent systems. The scope of this unprecedented protocol has been investigated with various substrates, clearly demonstrating its utility for the selective synthesis of two structural isomers from one substrate. Controlled experiments proved that the regiodivergency resulted from the switch of the migrating group.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kohsuke Ohmatsu, Takayuki Tanaka, Takashi Ooi, Keiji Maruoka,