| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224435 | Tetrahedron | 2009 | 4 Pages |
Abstract
The development of an efficient dehydration method of steroidal 4-en-3-ones by using chloranil and BSTFA in the presence of triflic acid in refluxing toluene allowed us, starting from testosterone, to set a large-scale procedure for the synthesis of the anti-cancer drug exemestane in 70% overall yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrés Marcos-Escribano, Francisco A. Bermejo, Antonio Lorente Bonde-Larsen, Jesús Iglesias Retuerto, Ignacio Herráiz Sierra,