| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224445 | Tetrahedron | 2009 | 5 Pages |
Abstract
Acetyl radical reacts as a nucleophilic radical with pyridinium ions, and as an electrophilic radical with pyridine through a mechanism involving multiorbital interactions. Electronwithdrawing groups on the pyridinium ring accelerates these reactions and is likely to be responsible for the chemistry observed for the tuberculosis drug isoniazid.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ruth I.J. Amos, Jason A. Smith, Brian F. Yates, Carl H. Schiesser,