Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224452 | Tetrahedron | 2009 | 6 Pages |
Abstract
Addition of alkyl iodides (3) into the solution containing 2-(or 4-)vinylpyridine (1 or 2) and carbonyl compounds (6) in the presence of Zn-powder (99.9%) in acetonitrile under refluxing brought about regio- and sequence-selective joining reaction of three components to give the corresponding (2-hydroxyethyl)pyridines (7 or 8) in good to moderate yields. On the other hand, 2-(2- or 4-pyridyl)ethyl alkyl ketones (10 or 11) were obtained from the similar joining reaction of three components by addition of alkyl iodides (3) into the solution of 2-(or 4-)vinylpyridine (1 or 2), and nitriles (9) in toluene containing Zn-powder (99.9%) under the similar reaction conditions.
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Related Topics
Physical Sciences and Engineering
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Authors
Kenji Mineyama, Hirofumi Maekawa, Akihiro Kohsaka, Yoshimasa Yamamoto, Ikuzo Nishiguchi,