| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224500 | Tetrahedron | 2010 | 6 Pages |
Abstract
Difluorination of 1-deoxynojirimycin at position C(3) creates a competitive inhibitor 15 of 10 times higher activity against an α-glucosidase than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
René Csuk, Erik Prell, Claudia Korb, Ralph Kluge, Dieter Ströhl,