Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224518 | Tetrahedron | 2010 | 8 Pages |
Abstract
A wide library of 3,7,8,8a-tetrahydro-2H-thiazolo[3,2-a]pyridines has been prepared by simple heating in acetonitrile of β-enaminonitriles, α,β-unsaturated aldehydes and 2-aminothiol hydrochlorides. Chemical yields depend on the nature, hindrance, and position of the substituents. The scope, limitations, and stereocontrol associated to this three-component reaction have been studied in detail. In general, the diastereoinduction observed in the three new stereogenic centers generated in the pro-chiral α,β-unsaturated aldehyde is low.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mónica Pérez Perrino, Rafael del Villar-Guerra, M. Carmen Sañudo, Luis A. Calvo, Alfonso González-Ortega,