Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224601 | Tetrahedron | 2010 | 4 Pages |
Abstract
A highly practical method to access β-sulfido carbonyl compounds was developed, which could be conducted without any expensive reagent, special apparatus/technique, and no requirement of metal catalysts. β-Sulfido carbonyl compounds were formed at room temperature, in short time and with high chemoselectivity in good to excellent yields. A plausible mechanism for the role of Rongalite®, as a promoter for the cleavage of disulfides generating thiolate anions that then undergo facile thia-Michael addition to α,β-unsaturated ketones and esters is proposed.
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Related Topics
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Chemistry
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Authors
Wenxue Guo, Guangshu Lv, Jiuxi Chen, Wenxia Gao, Jinchang Ding, Huayue Wu,