Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224631 | Tetrahedron | 2010 | 6 Pages |
Abstract
A simple, convenient, six-step synthesis of novel, tricyclic pyrazinebenzodiazepinedione derivatives has been described. The strategy is based on the use of the orthogonally-protected, optically pure, (S)-piperazine-2-carboxylic acid, in a Petasis reaction, followed by coupling with anthranilic acid and finally cyclizing cleavage. The investigated method was applied for the synthesis of novel bicyclic pyrazinediazepinedione derivatives. This traceless, solid-supported approach allows the preparation of a wide variety of compounds in moderate yields from commercially available or easily obtainable reagents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adam Mieczkowski, Janusz Jurczak,