| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224718 | Tetrahedron | 2008 | 8 Pages |
Abstract
Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding α-diethoxyphosphoryl-γ-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-β-substituted and β,γ-disubstituted α-methylene-γ-lactams. Cytotoxicity of these compounds was evaluated.
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