| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224720 | Tetrahedron | 2008 | 5 Pages |
Abstract
The first total synthesis of (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.
Graphical abstractDownload full-size imageThe first total synthesis of naturally occurring cytotoxyc dienynone (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefania Morandi, Federica Pellati, Stefania Benvenuti, Fabio Prati,