| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224729 | Tetrahedron | 2008 | 8 Pages |
Abstract
Chemical stability and reactivity of a bifunctional polymer conjugate containing an ortho-amino arylamide linkage have been successfully exploited to achieve a parallel synthesis of methoxycarbonylated head-tail bis-benzimidazoles. Regioselective alkylation of the two nitrogens in the benzimidazolone moiety has been carried out by ipso-fluoro displacement, and N-alkylation to generate two diversities. Cleavage of the polymer support has resulted in two libraries of di- and tri-substituted benzimidazolyl benzimidazolones in high purity and high yield. All reaction steps have been monitored by 1H NMR on the support directly.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hsia-Yuan Chen, Manohar V. Kulkarni, Chih-Hau Chen, Chung-Ming Sun,