| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224737 | Tetrahedron | 2008 | 4 Pages |
Abstract
An efficient route to γ-secretase inhibitor hydroxyl thiophene sulfonamide 1 is described. The approach contains nine steps with an overall yield of 8%. The synthesis highlights a diastereoselective methylation using Evans' oxazolidinone method and a chiral Strecker reaction via Davis' sulfonimine protocol.
Graphical abstractDownload full-size imageAn efficient route to γ-secretase inhibitor hydroxyl thiophene sulfonamide 1 is described. It highlights a diastereoselective methylation using Evans' oxazolidinone method and a chiral Strecker reaction via Davis' sulfonimine protocol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zheng Wang, Lynn Resnick,