Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224766 | Tetrahedron | 2010 | 8 Pages |
Abstract
A mild and efficient method for the synthesis of diverse isoindolinones from o-phthaldehydic acid methylthiomethyl ester and aliphatic/aromatic amines has been developed. A number of nucleophiles including a hydride ion were successfully added to the intermediate Schiff's base providing isoindolinones, with or without substitution at 3-position. Conditions have also been developed for amines with an integrated nucleophilic group to react in a diverse fashion either to give isoindolinones or tricyclic γ-lactams as single diastereoisomers in very good yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Usha Ghosh, Rituparna Bhattacharyya, Ashish Keche,