Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5224829 | Tetrahedron | 2009 | 6 Pages |
Abstract
Regioselective Michael addition of purine derivatives to α,β-unsaturated carbonyl compounds could be catalyzed by d-aminoacylase amano (DA) in DMSO. The influence of reaction conditions on the Michael addition, including solvent, temperature, and enzyme concentration was systematically investigated. Then we extended this methodology to six structurally diverse purine derivatives and a variety of α,β-unsaturated carbonyl compounds. 21 Michael adducts were selectively synthesized in moderate to high yields. It is the first report on enzyme-catalyzed Michael addition for the preparation of purine derivatives.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun-Liang Wang, Jian-Ming Xu, Qi Wu, De-Shui Lv, Xian-Fu Lin,