| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5224852 | Tetrahedron | 2008 | 8 Pages |
Abstract
A novel approach for the synthesis of 2,4-dialkyl-3-hydroxybutanolides, having three successive stereogenic centers, by an acid-catalyzed ring-switch reaction of 2-(2-hydroxyalkyl)lactams is described. This transformation was applied to the synthesis of the key intermediates of teromerase inhibitor UCS1025A.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chiaki Yamauchi, Masami Kuriyama, Rumiko Shimazawa, Tsumoru Morimoto, Kiyomi Kakiuchi, Ryuichi Shirai,